Title of article
A short approach to the bicyclo[4.3.0]nonane fragment of stawamycin
Author/Authors
Dias، نويسنده , , Luiz C. and Melgar، نويسنده , , Gliseida Z. and Jardim، نويسنده , , Luciana S.A.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
5
From page
4427
To page
4431
Abstract
The bicyclo[4.3.0]nonane (C11–C21) fragment of stawamycin has been prepared by a sequence involving 11 steps (10% overall yield) from methyl (R)-(−)-3-hydroxy-2-methylpropionate. Key steps are a Pd-catalysed Stille coupling reaction between a vinyl iodide and a vinyl stannane followed by an intramolecular Diels–Alder cycloaddition reaction to give the desired adduct as the major isomer in 21% overall yield.
Keywords
Pyrroloketoindane family , lactone , intramolecular Diels–Alder reaction , Stille coupling
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1846010
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