Author/Authors :
Prasad، نويسنده , , Ashok K. and Husain، نويسنده , , Mofazzal and Singh، نويسنده , , Brajendra K. and Gupta، نويسنده , , Rajinder K. and Manchanda، نويسنده , , Vijay K. and Olsen، نويسنده , , Carl E. and Parmar، نويسنده , , Virinder S.، نويسنده ,
Abstract :
Lipase-catalyzed enantioselective amidation was performed by reacting the racemic amine with aliphatic acids in nonsolvent system. The reaction equilibrium was shifted towards amide synthesis by the removal of water under reduced pressure. This methodology avoids the use of activating agents and hazardous solvents.
Keywords :
enantioselective , Lipase , Amidation , Bulk reaction , Chiral amide
