Author/Authors :
Meng، نويسنده , , Jun-cai and Fokin، نويسنده , , Valery V. and Finn، نويسنده , , M.G.، نويسنده ,
Abstract :
The use of chiral pybox ligands imparts enantioselectivity to the CuI-catalyzed azide–alkyne cycloaddition reaction, in the form of kinetic resolution of α-chiral azides and desymmetrization of gem-diazides. While levels of selectivity are modest, the results show unequivocally that the process benefits from ligand-accelerated catalysis.
