Title of article
Synthesis of (4R,15R,16R,21S)- and (4R,15S,16S,21S)-rollicosin
Author/Authors
Makabe، نويسنده , , Hidefumi and Higuchi، نويسنده , , Masaharu and Konno، نويسنده , , Hiroyuki and Murai، نويسنده , , Masatoshi and Miyoshi، نويسنده , , Hideto، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
5
From page
4671
To page
4675
Abstract
A convergent synthesis of (4R,15R,16R,21S)-rollicosin (1) and (4R,15S,16S,21S)-rollicosin (2) was accomplished. Hydroxy lactone 6a and/or 6b were synthesized from 4-pentyn-1-ol, and α,β-unsaturated lactone 7 was synthesized from γ-lactone 8 and 5-hexen-1-ol. Inhibitory activity of these compounds was examined with bovine heart mitochondrial complex I.
Keywords
Annonaceous acetogenin , antitumor , Mitochondrial complex I
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1846095
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