Synthesis of 3,4-disubstituted 2,5-dihydrofurans starting from the Baylis–Hillman adducts via consecutive radical cyclization, halolactonization, and decarboxylation strategy

A facile synthetic method of 3,4-disubstituted 2,5-dihydrofurans and 2,5-dihydropyrroles starting from the Baylis–Hillman adducts was developed. The 2,5-dihydrofuran skeleton was constructed via the consecutive radical cyclization, hydrolysis, halolactonization, and spontaneous decarboxylation strategy starting from the modified Baylis–Hillman adducts.