Author/Authors :
Fujiwara، نويسنده , , Kenshu and Kobayashi، نويسنده , , Masanori and Yamamoto، نويسنده , , Fuyuki and Aki، نويسنده , , Yuichi and Kawamura، نويسنده , , Mariko and Awakura، نويسنده , , Daisuke and Amano، نويسنده , , Seiji and Okano، نويسنده , , Azusa and Murai، نويسنده , , Akio and Kawai، نويسنده , , Hidetoshi and Suzuki، نويسنده , , Takanori، نويسنده ,
Abstract :
The common left-half [C31–C33(OC1–C7)–C40] part of pectenotoxins has been synthesized convergently from the C31–C35, C36–C40, and C1–C7 parts. The C31–C35 part, prepared via a new route shorter than our previous route, was coupled with the C36–C40 part through reductive lithiation and addition reactions to give an adduct stereoselectively, which was converted to a cyclic acetal corresponding to the C31–C40 part. The left-half was synthesized by a three-step process including esterification of the C31–C40 part with the C1–C7 part.
Keywords :
Reductive coupling reaction , natural product synthesis , Polyether macrolide , Pectenotoxin 2
