Title of article :
Traceless liquid-phase synthesis of 3-alkylamino-4,5-disubstituted-1,2,4-triazoles on polyethylene glycol (PEG)
Author/Authors :
Zong، نويسنده , , Ying-Xiao and Wang، نويسنده , , Jun-Ke and Yue، نويسنده , , Guo-Ren and Feng، نويسنده , , Lei and Song، نويسنده , , Zheng-En and Song، نويسنده , , Hai and Han، نويسنده , , Yu-Qi، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2005
Abstract :
A liquid-phase route to 3-alkylamino-4,5-disubstituted-1,2,4-triazoles has been developed, which permits the incorporation of three elements of diversity. The heterocycle was constructed upon PEG6000 (soluble polymer) modified by 4-hydroxy-2-methoxybenzaldehyde, from which a traceless cleavage could be realized with TFA/CH2Cl2. This method provided a library of 3-alkylamino-4,5-disubstituted-1,2,4-triazoles with reasonable yields and excellent purity.
Keywords :
Benzoyl hydrazine , Liquid-phase synthesis , Poly(ethylene glycol) (PEG) , 3-Alkylamino-4 , 5-Disubstituted-1 , 4-Triazoles , Arylacyl thiourea , 2
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
