Title of article :
Asymmetric synthesis of 3,3-disubstituted isoindolinones
Author/Authors :
Comins، نويسنده , , Daniel L. and Hiebel، نويسنده , , Anne-Cécile، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2005
Abstract :
An anionic chiral auxiliary-mediated asymmetric alkylation of carbamate 2 affords 3,3-disubstituted isoindolinones 3 in moderate to high de. The chiral auxiliary can be removed and recovered under mild conditions, and the resulting enantiopure lactams further elaborated.
Keywords :
chiral auxiliary , asymmetric synthesis , isoindolinones
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
