Title of article
TiF4-mediated biomimetic alkylation–cyclization cascade reaction of 2-trimethylsilylmethyl-1,5-dienes with aldehydes
Author/Authors
Anastasia ، نويسنده , , Luigi and Giannini، نويسنده , , Elios and Zanoni، نويسنده , , Giuseppe and Vidari، نويسنده , , Giovanni، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
4
From page
5803
To page
5806
Abstract
TiF4 has proven to be the Lewis acid of choice for promoting the biomimetic addition of 2-trimethylsilylmethyl-1,5-dienes to aliphatic aldehydes with concomitant cyclization. 1,3-cis-Disubstituted methylenecyclohexanes are thus produced in good yields and high diastereoselectivity. The reaction appears to proceed via a highly concerted mechanism involving a chair-like transition state.
Keywords
cyclization , biomimetic reactions , TiF4 , Allylsilane , Aldehydes
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1846493
Link To Document