Title of article :
Novel and efficient regioselective enzymatic approach to 3′-, 5′- and 3′,5′-di-O-crotonyl 2′-deoxynucleoside derivatives
Author/Authors :
Dيaz-Rodrيguez، نويسنده , , Alba and Fernلndez، نويسنده , , Susana and Lavandera، نويسنده , , Ivلn and Ferrero، نويسنده , , Miguel and Gotor، نويسنده , , Vicente، نويسنده ,
Abstract :
Regioselective syntheses of several O-crotonyl 2′-deoxynucleoside derivatives have been efficiently achieved using a biocatalytic methodology. While Candida antarctica lipase B (CAL-B) afforded the 5′-O-acylated compounds, immobilized lipase from Pseudomonas cepacia (PSL-C) provided the 3′-O-crotonylated analogs. Since classical chemical approaches did not work appropriately due to side isomerization reactions, a mixture of both lipases was used to achieve a useful synthetic route toward diacylated nucleosides.
