Author/Authors :
Huang، نويسنده , , Wei and Zhang، نويسنده , , Xu and Liu، نويسنده , , Hong and Shen، نويسنده , , Jianhua and Jiang، نويسنده , , Hualiang، نويسنده ,
Abstract :
Carboxylate-benzyl and nitro-benzyl groups used in phenols protection were selectively debenzylated with 3–25 equiv of Mg in methanol at room temperature. Good yields of the desired phenols were obtained within 3–10 h from a wide variety of O-(carboxylate-benzyl)- or O-(nitro-benzyl)-phenols. Selective O-debenzylation was possible in the presence of O-(carboxylate-benzyl)- or O-(nitro-benzyl)-phenols with Mg/MeOH.
Keywords :
Substituted benzyl , Phenol protecting group , Selective O-debenzylation , Mg/MeOH
