Total synthesis of HM-1 and HM-2, aromatic sesquiterpenes isolated from the phytopathogenic fungus Helicobasidium mompa. Structure revision of HM-2

The structure assigned to the sesquiterpene HM-2 was found to be incorrect by total synthesis. A ring-closing metathesis based strategy was developed for the total synthesis of the aromatic sesquiterpene HM-1, which on functional group transformation established the structure of HM-2 as 23, a cuparene derivative.