Title of article
A simple spiroepoxide as methionine aminopeptidase-2 inhibitor: synthetic problems and solutions
Author/Authors
Daniele and Rodeschini، نويسنده , , Vincent and de Weghe، نويسنده , , Pierre Van and Tarnus، نويسنده , , Céline and Eustache، نويسنده , , Jacques، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
5
From page
6691
To page
6695
Abstract
The preparation of a simple 1-oxa-spiro[2.4]heptane derivative is described. Observations made in the course of the synthesis show again that apparently minor structural modifications of the dienic substrate exert a strong influence on the ring-closing metathesis outcome and that the efficient construction of even simple but highly substituted systems by RCM may constitute a synthetic challenge.
Keywords
Fumagillin , Inhibition , MetAP-2 , RCM
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1846736
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