Synthesis of benzene-fused 1,7,8-trioxa-spiro[5.6]dodecanes

Two novel organic peroxides with one or two benzene rings fused to a 1,7,8-trioxaspiro[5.6]dodecan framework were synthesized, which provided the first examples of employing Kobayashi’s methodology in the synthesis of seven-membered peroxy rings. CSA was found to be a potent catalyst for introduction of the hydroperoxyl group, making a useful complement to Kobayashi’s methodology in constructing spiroperoxides.