Author/Authors :
Fujiwara، نويسنده , , Kenshu and Yoshimoto، نويسنده , , Saori and Takizawa، نويسنده , , Ayumi and Souma، نويسنده , , Shin-ichiro and Mishima، نويسنده , , Hirofumi and Murai، نويسنده , , Akio and Kawai، نويسنده , , Hidetoshi and Suzuki، نويسنده , , Takanori، نويسنده ,
Abstract :
Laurencin was efficiently synthesized from a C-glycoside derivative based on ring expansion of the oxane part of the starting compound into an eight-membered cyclic ether via a ring-cleavage/ring-closing olefin metathesis process, stereoselective introduction of a bromo group at C4, and convergent construction of the side-chain part using a lithiated enyne unit.
Keywords :
Ring-closing olefin metathesis , (+)-Laurencin , Marine natural product , total synthesis , Medium-ring ether
