Author/Authors :
Schِn، نويسنده , , Uwe and Messinger، نويسنده , , Josef and Buchholz، نويسنده , , Monika and Reinecker، نويسنده , , Uwe and Thole، نويسنده , , Hubert and Prabhu، نويسنده , , Manoj K.S. and Konda، نويسنده , , Ashok، نويسنده ,
Abstract :
An efficient Pd(0)-catalyzed protocol for the rapid and efficient preparation of 3-aminoestrone via 3-benzylaminoestrone from estrone–triflate is described. The three step synthesis proceeds with an overall yield of about 55% using X-Phos as optimal ligand for the Pd(0)-catalyzed Buchwald–Hartwig amination.
Keywords :
microwave , Buchwald–Hartwig amination , 3-aminoestrone , X-Phos , Steroids , PALLADIUM
