Title of article
A highly efficient, asymmetric synthesis of blastidic acid: the β-amino acid component of the antibiotic, (+)-blasticidin S
Author/Authors
Bischoff، نويسنده , , Roland and McDonald، نويسنده , , Niall and Sutherland، نويسنده , , Andrew، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
3
From page
7147
To page
7149
Abstract
A new approach for the asymmetric synthesis of blastidic acid, the β-amino acid component of the antibiotic, (+)-blasticidin S has been achieved in 11 steps and 30% overall yield. The key transformations involve a one-pot Swern/Wittig reaction sequence to prepare the carbon backbone followed by a stereoselective conjugate addition to introduce the β-amino functionality.
Keywords
?-Amino acid , antibiotic , conjugate addition , blastidic acid , asymmetric synthesis
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1846912
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