Title of article
Antimycobacterial natural products: synthesis and preliminary biological evaluation of the oxazole-containing alkaloid texaline
Author/Authors
Giddens، نويسنده , , Anna C. and Boshoff، نويسنده , , Helena I.M. and Franzblau، نويسنده , , Scott G. and Barry III، نويسنده , , Clifton E. and Copp، نويسنده , , Brent R.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
3
From page
7355
To page
7357
Abstract
Texaline, an antimycobacterial oxazole-containing alkaloid previously isolated from Amyris texana and A. elemifera, and related compounds have been synthesized in order to explore aspects of the structure–antituberculosis activity relationship. While texaline was found to be inactive in our assays, simpler diaryloxazoles were more active whilst also exhibiting modest toxic selectivity, leading to their identification as potential lead compounds.
Keywords
natural product , alkaloid , Texaline , Tuberculosis
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1847007
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