Title of article :
Synthesis of 5-aza-analogues of angucyclines: manipulation of the 2-deoxy-C-glycoside subunit
Author/Authors :
Vu، نويسنده , , Nguyen Quang and Dujardin، نويسنده , , Gilles and Collet، نويسنده , , Sylvain C. and Raiber، نويسنده , , Eun-Ang and Guingant، نويسنده , , André Y. and Evain، نويسنده , , Michel، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2005
Abstract :
Based on a heterocyclic Diels–Alder strategy, a concise synthesis of 5-aza-analogues of angucyclines bearing a 2-deoxy-C-glycoside subunit is reported. Starting from a common intermediate, a peracetylated D-2-deoxyglucose could be linked to carbons C9 or C10 of the tetracyclic framework. Further manipulations of the sugar residue allowed the installation of bromo and azido substituents at carbon C6′.
Keywords :
angucycline , Angucyclinone , Angucycline-5-aza-analogue , 2-Aza-1 , 3-diene , 2-Bromo-naphtoquinone , Hetero-Diels–Alder reaction , C-glycoside
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
