Title of article
Semipermanent p-nitrobenzyloxycarbonyl (pNZ) protection of Orn and Lys side chains: prevention of undesired α-Fmoc removal and application to the synthesis of cyclic peptides
Author/Authors
Isidro-Llobet، نويسنده , , Albert and ءlvarez، نويسنده , , Mercedes and Albericio، نويسنده , , Fernando، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
4
From page
7733
To page
7736
Abstract
Semipermanent side-chain protection of Orn and Lys with p-nitrobenzyloxycarbonyl (pNZ) for Fmoc/tBu chemistry does not result in the unwanted removal of α-Fmoc that occurs when groups such as Alloc are used for the same application. Furthermore, pNZ can be used in conjuction with p-nitrobenzyl ester (pNB) to prepare cyclic peptides.
Keywords
Side reactions , Combinatorial chemistry , Orthogonal protecting group
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1847202
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