Title of article
Oligothiophene phosphoramidites for oligonucleotide labelling
Author/Authors
Capobianco، نويسنده , , Massimo L. and Naldi، نويسنده , , Marina and Zambianchi، نويسنده , , Massimo and Barbarella، نويسنده , , Giovanna، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
4
From page
8181
To page
8184
Abstract
We report the synthesis and characterization of two oligonucleotides (a tetramer and a 19-mer) labelled with a fluorescent oligothiophene and obtained by means of the phosphoramidite of the fluorophore. The conjugate compounds were synthesized in solid phase and characterized by means of mass spectrometry, multinuclear NMR, UV–vis and photoluminescence spectroscopies. The results show that this approach is suitable as a general route for the preparation of oligonucleotides labelled with oligothiophene-based fluorophores.
Keywords
Oligothiophenes , Molecular probes , fluorescence , Synthesis , oligonucleotides
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1847501
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