Author/Authors :
Nikkhoo، Mohammad نويسنده Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran , , Kuo، Ya-Wen نويسنده Institute of Biomedical Engineering, College of Medicine and Engineering, National Taiwan University, Taipei, Taiwan , , Hsu، Yu-Chun نويسنده Institute of Biomedical Engineering, College of Medicine and Engineering, National Taiwan University, Taipei, Taiwan , , Khalaf، Kinda نويسنده Department of Biomedical Engineering, Khalifa University of Science, Technology and Research, Abu Dhabi, UAE , , Haghpanahi، Mohammad نويسنده School of Mechanical Engineering, Iran University of Science and Technology, Tehran, Iran , , Parnianpour، Mohamad نويسنده Department of Industrial & Manufacturing, University of Wisconsin, Milwaukee, USA , , Wang، Jaw-Lin نويسنده Institute of Biomedical Engineering, College of Medicine and Engineering, National Taiwan University, Taipei, Taiwan ,
Abstract :
The investigation of dynamic response of intervertebral disc is beneficial for the development of new synthetic and engineered tissues for treating diseased or injured disc. There are limited experimental studies on comparing the effect of loading mode and rate on global response of intervertebral disc. In this study, in-vitro experiments were performed using a total of 24 porcine motion segments. The harvested specimens were assigned to prolong and 2 different cyclic loadings. Both disc deformations and water contents were measured to investigate how the mode and rate of loading affect the response of intervertebral disc. In parallel, a backward FE poroelastic model combined with in-vitro experiments were used to find the material properties of intervertebral discs. The experimental result showed that the final disc height loss under creep loading was significantly greater than cyclic groups. Increasing the frequency of cyclic loading decreased the disc height loss. The water content decreased significantly in cyclic loading from those in prolong loading. The backward FE models showed that, the elastic modulus of anulus fibrosus and nucleus pulposus were 2.43 (±0.48) MPa and 1.46 (±0.29) MPa, respectively. The hydraulic permeability was 2.08 (±0.42) ×10-16m4/Ns, and the Poisson’s ratio was 0.21 (±0.03). In conclusion, this study investigated how the loading mode and rate affect porcine intervertebral disc deformation. It is found that dynamic stiffness is greater at higher frequencies which resulted from interactions between the solid phase and fluid flow within the disc.
