Title of article
Electrogenerated cyanomethyl anion in organic synthesis: a simple diastereoselective synthesis of cis-3-alkyl-1-benzyl-4-ethoxycarbonyl-β-lactams
Author/Authors
Feroci، نويسنده , , Marta and Lessard، نويسنده , , Jean and Orsini، نويسنده , , Monica and Inesi، نويسنده , , Achille، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
3
From page
8517
To page
8519
Abstract
A ready diastereoselective synthesis of cis-3-alkyl-1-benzyl-4-ethoxycarbonyl-β-lactams has been developed by galvanostatic electrolysis of MeCN–Et4NPF6 solutions and subsequent addition of a N-(ethoxycarbonyl)methyl-N-benzyl-2-bromoalkylcarboxamide. The yields in β-lactams are very high and the cis isomers have been obtained in a large excess, the cis/trans ratios varying from 87/13 to 93/07.
Keywords
?-Lactams , Electrosynthesis , Cathodic reduction , Electrogenerated cyanomethyl anion
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1847787
Link To Document