Title of article :
Practical enantioselective synthesis of lamivudine (3TC™) via a dynamic kinetic resolution
Author/Authors :
Goodyear، نويسنده , , Michael D. and Hill، نويسنده , , Malcolm L. and West، نويسنده , , Jono P. and Whitehead، نويسنده , , Andrew J.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2005
Abstract :
A practical enantioselective synthesis of lamivudine 1 is described. A highly effective dynamic kinetic resolution of the 5-hydroxyoxathiolane, followed by chlorination and introduction of cytosine provides an efficient synthesis of lamivudine.
Keywords :
practical , enantioselective , dynamic kinetic resolution , Lamivudine
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
