Title of article
Practical enantioselective synthesis of lamivudine (3TC™) via a dynamic kinetic resolution
Author/Authors
Goodyear، نويسنده , , Michael D. and Hill، نويسنده , , Malcolm L. and West، نويسنده , , Jono P. and Whitehead، نويسنده , , Andrew J.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
4
From page
8535
To page
8538
Abstract
A practical enantioselective synthesis of lamivudine 1 is described. A highly effective dynamic kinetic resolution of the 5-hydroxyoxathiolane, followed by chlorination and introduction of cytosine provides an efficient synthesis of lamivudine.
Keywords
practical , enantioselective , dynamic kinetic resolution , Lamivudine
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1847793
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