Title of article :
Total synthesis of (±)-cyclooroidin
Author/Authors :
Gianluca Papeo، نويسنده , , Gianluca and Frau، نويسنده , , Marيa Antonia Gَmez-Zurita and Borghi، نويسنده , , Daniela and Varasi، نويسنده , , Mario، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2005
Abstract :
The first total synthesis of (±)-cyclooroidin, a member of the pyrrole–imidazole alkaloid family recently isolated from the sponge Agelas oroides in optically pure form, is described. The synthesis was achieved in nine linear steps, with an overall yield of 10%. Key step was a Wolff bromoketone synthesis performed on the intermediate longamide B.
Keywords :
pyrrole–imidazole alkaloids , Cyclooroidin , Wolff bromoketone synthesis
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
