Title of article
New sesquiterpene lactones from water extract of the root of Lindera strychnifolia with cytotoxicity against the human small cell lung cancer cell, SBC-3
Author/Authors
Ohno، نويسنده , , Takamasa and Nagatsu، نويسنده , , Akito and Nakagawa، نويسنده , , Munehiro and Inoue، نويسنده , , Makoto and Li، نويسنده , , Yun-Mo and Minatoguchi، نويسنده , , Shinya and Mizukami، نويسنده , , Hajime and Fujiwara، نويسنده , , Hisayoshi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
4
From page
8657
To page
8660
Abstract
In the present study, new sesquiterpene lactones (1) and (2) were isolated from the EtOAc soluble fraction of the water extract of Linderae Radix through bioassay-guided fractionation and isolation methods. The structure of these compounds was elucidated by spectroscopic analysis of their 2D NMR spectra, including COSY, HMBC, and HMQC techniques. Two isolates showed significant cytotoxicity against the human small cell lung cancer cell SBC-3, and lesser cytotoxicity against mouse fibroblast cell 3T3-L1.
Keywords
Antitumor activity , Lindera strychnifolia , Sesquiterpene lactone , Lauraceae
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1847829
Link To Document