Author/Authors :
Fialov?، نويسنده , , Pavla and Carmona، نويسنده , , Ana T. and Robina، نويسنده , , Inmaculada and Ettrich، نويسنده , , Rüdiger and Sedmera، نويسنده , , Petr and P?ikrylov?، نويسنده , , V?ra and Petr?skov?-Hu??kov?، نويسنده , , Lucie and K?en، نويسنده , , Vladim?r، نويسنده ,
Abstract :
Glycosyl azides are new efficient donors for glycosidases. Their high water solubility facilitates transglycosylations with comparable or better yields than common O-glycosides. The azido group totally changes the β-GalNAc-ase/β-GlcNAc-ase ratio in β-N-acetylhexosaminidases (from the usual 0.3–1.0 to <0.01), contrary to all known aglycons.
Keywords :
molecular modelling , ?-N-acetylhexosaminidase , enzyme catalysis , glycosyl azide
