Title of article
A mild and highly convenient chemoselective alkylation of thiols using Cs2CO3–TBAI
Author/Authors
Salvatore، نويسنده , , Ralph Nicholas and Smith، نويسنده , , Robert A. and Nischwitz، نويسنده , , Adam K. and Gavin، نويسنده , , Terrence، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
5
From page
8931
To page
8935
Abstract
A mild and improved method for the synthesis of thioethers has been developed. In the presence of cesium carbonate, tetrabutylammonium iodide, and DMF, various alkyl and aryl thiols underwent S-alkylation to afford structurally diverse sulfides in high yield. Unprotected mercaptoalcohols and thioamines reacted chemoselectively at the sulfur moiety exclusively. An example of a one-pot, solid-phase synthesis of a thioether is also described.
Keywords
tetrabutylammonium iodide , Thioethers , Alkyl halides , cesium carbonate , thiols
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1847902
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