Author/Authors :
Kim، نويسنده , , Soyoung and Su، نويسنده , , Bao-Ning and Riswan، نويسنده , , Soedarsono and Kardono، نويسنده , , Leonardus B.S. and Afriastini، نويسنده , , Johar J. and Gallucci، نويسنده , , Judith C. and Chai، نويسنده , , Heebyung and Farnsworth، نويسنده , , Norman R. and Cordell، نويسنده , , Geoffrey A. and Swanson، نويسنده , , Steven M. and Kinghorn، نويسنده , , A. Douglas، نويسنده ,
Abstract :
Two benzo[b]oxepine derivatives, edulisones A (1) and B (2), were isolated from the bark of Aglaia edulis, collected in Indonesia. The relative stereochemistry of 1 was determined by single-crystal X-ray diffraction analysis. Treatment of compounds 1 and 2 with lithium hydroxide produced the same hydrolysis products, 1a and 1b, as a result of cleavage of the pyrrolidine ring to an alkylated amide mixture in each case, which demonstrated that these substances are epimeric at their 2-aminopyrrolidine moiety.
Keywords :
Epimers , Edulisones A and B , X-ray analysis , alkaline hydrolysis , Aglaia edulis , Meliaceae , NMR data
