Author/Authors :
Hoshina، نويسنده , , Yoichiro and Ikegami، نويسنده , , Satoru and Fujimoto، نويسنده , , Kyoko and Okuyama، نويسنده , , Akihiko and Harada، نويسنده , , Tatsuhiro and James، نويسنده , , Susan and Griffiths، نويسنده , , Peter G. and Wu، نويسنده , , Zemin and Lilly، نويسنده , , Michael and Bray، نويسنده , , Andrew M.، نويسنده ,
Abstract :
2,3-Diphenylpropionic acid library for VLA-4 antagonist was synthesized on solid-phase. Comparison of the two synthetic routes via an orthogonal generation of two aromatic amino functional groups are discussed. From this work, several compounds were identified as potent VLA-4 antagonists.
Keywords :
solid-phase synthesis , 2 , VLA-4 antagonist , 3-Diphenylpropionic acid
