Title of article
Solid-phase synthesis of 2,3-diphenylpropionic acid library as VLA-4 antagonists
Author/Authors
Hoshina، نويسنده , , Yoichiro and Ikegami، نويسنده , , Satoru and Fujimoto، نويسنده , , Kyoko and Okuyama، نويسنده , , Akihiko and Harada، نويسنده , , Tatsuhiro and James، نويسنده , , Susan and Griffiths، نويسنده , , Peter G. and Wu، نويسنده , , Zemin and Lilly، نويسنده , , Michael and Bray، نويسنده , , Andrew M.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
4
From page
9035
To page
9038
Abstract
2,3-Diphenylpropionic acid library for VLA-4 antagonist was synthesized on solid-phase. Comparison of the two synthetic routes via an orthogonal generation of two aromatic amino functional groups are discussed. From this work, several compounds were identified as potent VLA-4 antagonists.
Keywords
solid-phase synthesis , 2 , VLA-4 antagonist , 3-Diphenylpropionic acid
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1847937
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