Title of article
Three-component synthesis of hexahydropyridopyrimidine–spirocyclohexanetriones induced by microwave
Author/Authors
Quiroga، نويسنده , , Jairo and Cruz، نويسنده , , Silvia and Insuasty، نويسنده , , Braulio and Abonيa، نويسنده , , Rodrigo and Nogueras، نويسنده , , Manuel and Cobo، نويسنده , , Justo، نويسنده ,
Issue Information
دوماهنامه با شماره پیاپی سال 2006
Pages
4
From page
27
To page
30
Abstract
Pyridopyrimidine–spirocyclohexanetriones (5, 6) and pyrimido[4,5-b]quinolinones (8) were obtained in a three-component microwave-assisted reaction of 6-aminopyrimidin-4-ones (1) with dimedone (2) and formaldehyde solution or paraformaldehyde, respectively. A mechanism is proposed based on the presence of a basic catalyst (triethylamine in this case) and the fact that single condensation intermediates are isolated prior to the cyclization leading to the final products.
Keywords
6-aminopyrimidine , Dimedone , 3-d]pyrimidine , 5-b]quinoline , Basic catalyst , microwave irradiation , Formaldehyde
Journal title
Tetrahedron Letters
Serial Year
2006
Journal title
Tetrahedron Letters
Record number
1847955
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