Title of article
Synthesis and reactivity of N-hydroxy-2-aminoindoles
Author/Authors
Belley، نويسنده , , Michel and Sauer، نويسنده , , Effiette and Beaudoin، نويسنده , , Daniel and Duspara، نويسنده , , Petar and Trimble، نويسنده , , Laird A. and Dubé، نويسنده , , Pascal، نويسنده ,
Issue Information
دوماهنامه با شماره پیاپی سال 2006
Pages
4
From page
159
To page
162
Abstract
Catalytic hydrogenation of (2-nitrophenyl)acetonitriles bearing an electron-withdrawing substituent α to the nitrile, using Pd/C and (Ph3P)4Pd, affords N-hydroxy-2-aminoindoles in good to excellent yields. (Ph3P)4Pd decreases the reduction rate of the intermediate hydroxylamine and acts as a catalyst during the cyclization onto the nitrile.
Keywords
reductive cyclization , N-Hydroxy-2-aminoindole , Tetrakis(triphenylphosphine)palladium(0) , Catalytic hydrogenation , (Ph3P)4Pd
Journal title
Tetrahedron Letters
Serial Year
2006
Journal title
Tetrahedron Letters
Record number
1848008
Link To Document