Author/Authors :
Cordes، نويسنده , , David B. and Kwong، نويسنده , , Tracey J. and Morgan، نويسنده , , Kellie A. and Singaram، نويسنده , , Bakthan، نويسنده ,
Abstract :
High enantioselectivities are obtained for the preparation of chiral styrene oxides through reduction of α-haloacetophenones using TarB-NO2 reagent and the inexpensive and mild reducing agent NaBH4. The epoxides are easily obtained in up to 95% ee through routine acid–base workup of the product alcohols. Either the (R) or (S) epoxide can be obtained by using the appropriate l- or d-tartaric acid starting material in the TarB-NO2 reagent.
