Author/Authors :
Zanatta، نويسنده , , Nilo and Flores، نويسنده , , Darlene C. and Madruga، نويسنده , , Claudia C. and Flores، نويسنده , , Alex F.C. and Bonacorso، نويسنده , , Helio G. and Martins، نويسنده , , Marcos A.P.، نويسنده ,
Abstract :
This work reports a two-step synthetic strategy to obtain a series of 6-methylenesubstituted-4-trichloromethyl-2-methylsulfanylpyrimidines from the cyclization of 5-bromo-4-methoxy-1,1,1-trichloro-pent-3-en-2-ones with 2-methyl-2-pseudothiourea sulfate, followed by nucleophilic substitution of 6-bromomethyl-4-trichloromethyl-2-methylsulfanylpyrimidine with a series of nucleophiles. Alternative strategies to obtain 6-halomethyl-4-trichloro[fluoro]methyl-2-methylsulfanyl pyrimidines have been addressed.
