Author/Authors :
Yoshimura، نويسنده , , Yuichi and Kuze، نويسنده , , Tetsuya and Ueno، نويسنده , , Mari and Komiya، نويسنده , , Fumiko and Haraguchi، نويسنده , , Kazuhiro and Tanaka، نويسنده , , Hiromichi and Kano، نويسنده , , Fumitaka and Yamada، نويسنده , , Kohei and Asami، نويسنده , , Kazuhiro and Kaneko، نويسنده , , Nobuaki and Takahata، نويسنده , , Hiroki، نويسنده ,
Abstract :
A practical synthesis of 4′-thioribonucleosides starting from inexpensive l-arabinose is described. 1,4-Anhydro-2,3-O-isopropylidene-4-thioribitol, which was prepared by using a novel reductive ring-contraction reaction, was converted to the 5-O-silylated sulfoxides. The Pummerer-type thioglycosylation of the sulfoxides gave the 4′-thioribonucleosides stereoselectively.
