Title of article
Differential effects of chemoattractants on mast cell recruitment in vivo
Author/Authors
de Cلssia Campos Bertoncini، نويسنده , , Maria Rita and Toso، نويسنده , , Vanina Danuza and de Souza Jr.، نويسنده , , Devandir Antonio and Vieira، نويسنده , , Gabriel Viliod and da Silva، نويسنده , , Elaine Zayas Marcelino and Oliver، نويسنده , , Constance and Jamur، نويسنده , , Maria Célia، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2014
Pages
5
From page
86
To page
90
Abstract
Rats were injected with rat recombinant (rr) IL3, rrSCF, rrIL-3 + rrSCF, rrRANTES and LTB4. Six hours after subcutaneous injection of rrIL-3 or rrIL-3 + rrSCF, there was an increase in mast cell numbers in the skin and spleen. Peritoneal mast cells were recruited following i.p. injection of rrIL-3, but with rrIL-3 + rrSCF recruitment was delayed. Immunostaining with a mast cell specific antibody showed that immature orthochromatic mast cells were being recruited. rrIL-3 induced recruitment of mast cells to the peritoneal cavity was blocked by anti-integrin antibodies. Mast cell recruitment depended on the target tissue and the time of exposure to the chemoattractant.
Keywords
SCF , LTB4 , RANTES , IN VIVO , mast cells , Recruitment , IL-3
Journal title
Cellular Immunology
Serial Year
2014
Journal title
Cellular Immunology
Record number
1848678
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