Author/Authors :
Lee، نويسنده , , Ha-Reum and Huh، نويسنده , , Scarlett Yoona and Hur، نويسنده , , Dae Young and Jeong، نويسنده , , Hyuk and Kim، نويسنده , , Tae-Sung and Kim، نويسنده , , Sang Yoon and Park، نويسنده , , Seung Beom and Yang، نويسنده , , Yoolhee and Bang، نويسنده , , Sa Ik and Park، نويسنده , , Hyunjeong and Cho، نويسنده , , Daeho، نويسنده ,
Abstract :
Erythroid differentiation regulator 1 (ERDR1), which is a stress-related survival factor, exhibits anti-cancer effects against melanoma. However, the function of ERDR1 on immune cells has not been examined. We investigated whether ERDR1 regulates the cytotoxic ability of human natural killer (NK) cells, which are known as innate effector lymphocytes. In this study, treatment with recombinant ERDR1 resulted in enhanced NK cell cytotoxicity through the secretion of lytic granules. Furthermore, actin modulation was involved in the ERDR1-enhanced NK cell cytotoxicity. ERDR1 stimulated actin accumulation at the immunological synapse, which was induced by the activation of Vav-1 in NK cells. These findings suggest new insight into the function of ERDR1 function in the human immune system.
Keywords :
Actin , Natural Killer cell , Erythroid differentiation regulator 1 , cytotoxicity , Immune system
