Microwave-assisted coupling with DIC/HOBt for the synthesis of difficult peptoids and fluorescently labelled peptides—a gentle heat goes a long way

Mild thermal effects (Arrhenius based) achieved with microwave heating proved to be highly successful in enabling rapid and efficient secondary amine couplings and the labelling of peptides with a variety of fluorophores and quenchers in high yields and purities with just traditional, yet robust, HOBt/DIC chemistry.