Author/Authors :
Doi، نويسنده , , Takayuki and Iijima، نويسنده , , Yusuke and Shin-ya، نويسنده , , Kazuo and Ganesan، نويسنده , , A. and Takahashi، نويسنده , , Takashi، نويسنده ,
Abstract :
We achieved the total synthesis of the histone deacetylase inhibitor spiruchostatin A, as the prelude to the preparation of a combinatorial library of its analogues. Two key reactions were an asymmetric acetate aldol reaction using a Zr-enolate and macrolactonization using the Shiina method.
Keywords :
spiruchostatin , Cyclic depsipeptide , natural product synthesis , Asymmetric aldol reaction
