Author/Authors :
Voight، نويسنده , , Eric A. and Bodenstein، نويسنده , , Matthew S. and Ikemoto، نويسنده , , Norihiro and Kress، نويسنده , , Michael H.، نويسنده ,
Abstract :
Conditions have been developed for the selective reduction of N-Boc-protected amino acid-derived secondary amides, avoiding the formation of overreduction and cyclic urea byproducts. The method is showcased by the efficient formal synthesis of NK-1 antagonist LY303870.
