Author/Authors :
Bose، نويسنده , , Ajay K. and Ganguly، نويسنده , , Subhendu N. and Manhas، نويسنده , , Maghar S. and Rao، نويسنده , , Sheetal and Speck، نويسنده , , Jeffrey and Pekelny، نويسنده , , Uri and Pombo-Villars، نويسنده , , Esteban، نويسنده ,
Abstract :
Highly accelerated and safe nitration of phenolic compounds has been found to be feasible with a mixture of calcium nitrate and acetic acid as an efficient nitration agent under brief microwave irradiation. This method is compatible with the green chemistry approach because calcium salts—the inorganic byproducts—can be useful agrochemicals rather than waste chemicals. Commercially available 15N-labeled calcium nitrate is convenient for the preparation of 15N-labeled compounds for metabolic studies and mass spectrometry. This safe nitration method can be included in laboratory experiments for high school and college students.
Keywords :
Microwave-assisted nitration , Green chemistry approach , Mononitro phenol , Calcium nitrate for nitration , 15N-labeled compounds
