Author/Authors :
Zhong، نويسنده , , Boyu and Al-Awar، نويسنده , , Rima S. and Shih، نويسنده , , Chuan and Grimes Jr.، نويسنده , , John H. and Vieth، نويسنده , , Michal and Hamdouchi، نويسنده , , Chafiq، نويسنده ,
Abstract :
4-Quinolyl isothiocyanates were synthesized in a regiospecific fashion from the corresponding 4-chloroquinolines and silver thiocyanate in refluxing toluene. The products were isolated in quantitative yield and high purity (>95%) by simple filtration and concentration. Reactivity and mechanism of the reaction are discussed. The new approach would provide a new mean which had been lacking for the synthesis of functionalized 4-quinolinyl isothiocyanate.
