Author/Authors :
Akiyama، نويسنده , , Megumi and Isoda، نويسنده , , Yuichi and Nishimoto، نويسنده , , Masato and Narazaki، نويسنده , , Maiko and Oka، نويسنده , , Hiroaki and Kuboki، نويسنده , , Atsuhito and Ohira، نويسنده , , Susumu، نويسنده ,
Abstract :
The absolute stereochemistry of plakortone E, a cytotoxic metabolite of the Caribbean sponge, was established to be 1, by the synthesis of the racemic C-8 epimer (±)-2 and then of (−)-1 itself, which was identical with the natural compound.
Keywords :
Plakortone E , alkylidenecarbene , Absolute stereochemistry , C–H insertion
