A facile synthesis of chiral polyazamacrocycles and the UV spectroscopic and CD spectra studies on metal complexes

A series of chiral polyazamacrocycles with 12, 18, 24, 27, 36-membered rings were designed and synthesized using (S)-α-phenylethylamine as initial chiral source. Herein 11 new chiral polyazamacrocycles were successfully prepared. The UV spectroscopic titration experiments of polyazamacrocycle 3b with metal ions were carried out and the binding constants and free energy changes were calculated according to the modified Benesi–Hildebrand equation. Circular dichroism spectra were recorded for 3b with metal ions.