Title of article
A new convenient route to enantiopure 2-coumarinyloxypropanals: application to the synthesis of optically active geiparvarin analogues
Author/Authors
Chimichi، نويسنده , , Stefano and Boccalini، نويسنده , , Marco and Cravotto، نويسنده , , Giancarlo and Rosati، نويسنده , , Ornelio، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2006
Pages
4
From page
2405
To page
2408
Abstract
A new convenient route to enantiopure 2-coumarinyloxypropanals is described: Rosenmund reduction of (R)- or (S)-2-coumarinyloxypropanoyl chlorides afforded in good yields the corresponding 2-coumarinyloxypropanals. Their subsequent aldolic condensation with 3(2H)-furanones, followed by dehydration, led to enantiopure geiparvarin analogues now being investigated as promising antitumoral compounds.
Keywords
geiparvarin analogues , antitumoral compounds , Enantiopure 2-coumarinyloxypropanals
Journal title
Tetrahedron Letters
Serial Year
2006
Journal title
Tetrahedron Letters
Record number
1849446
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