Title of article
Dual side-reactions limit the utility of a key polymer therapeutic precursor
Author/Authors
Devenish، نويسنده , , Sean R.A. and Hill، نويسنده , , Jonathan B. and Blunt، نويسنده , , John W. and Morris، نويسنده , , Jonathan C. and Munro، نويسنده , , Murray H.G. Munro، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2006
Pages
4
From page
2875
To page
2878
Abstract
In contrast to literature reports, the activated polyacid poly(methacryloxysuccinimide) reacts with nucleophiles to give, initially, a high proportion of ring-opened residues. This copolymer then reacts intramolecularly to form a polymer with a high fraction of glutarimide residues. These side reactions occur to such an extent as to preclude the use of poly(methacryloxysuccinimide) as a precursor to polymethacrylamides.
Keywords
Chemoselectivity , pMAOS , NHS ester , pHPMA , NMR spectroscopy , Structure elucidation
Journal title
Tetrahedron Letters
Serial Year
2006
Journal title
Tetrahedron Letters
Record number
1849740
Link To Document