Author/Authors :
Limbeck، نويسنده , , Marcus and Wamhoff، نويسنده , , Heinrich and Rِlle، نويسنده , , Thomas and Griebenow، نويسنده , , Nils، نويسنده ,
Abstract :
The palladium-catalyzed α-arylation of ketones on solid support is described. Using modified Buchwald–Hartwig reaction conditions, the coupling of immobilized 4-bromobenzamide with various aromatic, heteroaromatic, and aliphatic ketones was investigated. Subsequent cleavage from the resin provided the desired α-aryl ketones almost in moderate to high yields and good to excellent purities. The scope and limitations of this protocol will be discussed.
