Title of article
Palladium-catalyzed α-arylation of ketones on solid support: scope and limitations
Author/Authors
Limbeck، نويسنده , , Marcus and Wamhoff، نويسنده , , Heinrich and Rِlle، نويسنده , , Thomas and Griebenow، نويسنده , , Nils، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2006
Pages
4
From page
2945
To page
2948
Abstract
The palladium-catalyzed α-arylation of ketones on solid support is described. Using modified Buchwald–Hartwig reaction conditions, the coupling of immobilized 4-bromobenzamide with various aromatic, heteroaromatic, and aliphatic ketones was investigated. Subsequent cleavage from the resin provided the desired α-aryl ketones almost in moderate to high yields and good to excellent purities. The scope and limitations of this protocol will be discussed.
Journal title
Tetrahedron Letters
Serial Year
2006
Journal title
Tetrahedron Letters
Record number
1849779
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