Title of article
β-Tosylethylazide: a useful synthon for preparation of N-protected 1,2,3-triazoles via click chemistry
Author/Authors
Yap، نويسنده , , Amy H. and Weinreb، نويسنده , , Steven M.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2006
Pages
4
From page
3035
To page
3038
Abstract
β-Tosylethylazide (TSE-N3), which can be prepared in one step from p-tolyl vinyl sulfone and sodium azide/H2SO4, undergoes metal-catalyzed 1,3-dipolar cycloadditions with alkynes to produce TSE-protected 1,2,3-triazoles. The protecting group can be removed using potassium tert-butoxide in THF at −78 to 0 °C.
Keywords
1 , 3-dipolar cycloadditions , 1 , protecting groups , 2 , 3-Triazoles , Nitrogen Heterocycles
Journal title
Tetrahedron Letters
Serial Year
2006
Journal title
Tetrahedron Letters
Record number
1849820
Link To Document