Title of article :
Ileabethoxazole: a novel benzoxazole alkaloid with antimycobacterial activity
Author/Authors :
Rodrيguez، نويسنده , , Ileana I. and Rodrيguez، نويسنده , , Abimael D. and Wang، نويسنده , , Yuehong and Franzblau، نويسنده , , Scott G.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2006
Abstract :
Ileabethoxazole (1), a new perhydroacenaphthene-type diterpene alkaloid containing the uncommon benzoxazole moiety, was isolated from the Caribbean sea whip Pseudopterogorgia elisabethae. The structure of 1 was elucidated by extensive spectroscopic data interpretation. Ileabethoxazole showed 92% inhibition of Mycobacterium tuberculosis (H37Rv) at the concentration range of 128–64 μg/mL.
Keywords :
Tuberculosis , Pseudopterogorgia elisabethae , Caribbean gorgonian octocorals , Ileabethane skeleton , Mycobacterium , benzoxazole
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
