Novel nucleotide–calixarene conjugates via phosphoester linkage

Calix[4]arenes bearing thymine, adenine, cytosine, guanine 2′-deoxynucleotide residues have been synthesized following the phosphoramidite chemistry. Hybrid compounds 2a–d and 3a–d represent the first example of nucleotides linked to the calixarene lower rim by a phosphoester bond. Preliminary studies about their assembling in apolar solvent and host properties toward biologically interesting guests are also reported.